Intention: Process parameters significantly influence the product quality and therapeutic effectiveness during the production of biopharmaceuticals, e.g., antibodies. In order to provide an efficient production even when undertaking post-translational agent modification, process control concepts are necessary which monitor, shelve and adjust the most important process parameters. The “CHO-KI” cooperation project’s goal is to develop a new, flexible and robust technology to regulate biotechnological production processes in industrial settings online.